Waxyaabaha lagu daro quudinta: Tributyrin

Mawduuca: 95%, 90%

Tributyrin oo ah wax lagu daro quudinta si loo hagaajiyo caafimaadka mindhicirka ee digaagga.

Joojinta antibiyootikada iyada oo ah dhiirrigeliyeyaasha koritaanka ee cuntooyinka quudinta digaagga ayaa kordhisay xiisaha loo qabo xeelado kale oo nafaqo, si loo kordhiyo waxqabadka digaagga iyo sidoo kale looga hortago khalkhalka cudurrada.

Yaraynta raaxo-darrada dysbacteriosis
Si loo hubiyo xaaladaha dysbacteriosis, waxyaabaha lagu daro quudinta sida probiotics iyo prebiotics ayaa lagu darayaa si loo saameeyo soo saarista SCFAs, gaar ahaan butyric acid kaas oo door muhiim ah ka ciyaara ilaalinta hufnaanta marinnada mindhicirka. Butyric acid waa SCFA dabiici ah oo leh saameyn badan oo faa'iido leh sida saameynteeda ka hortagga bararka, saameynta ay ku leedahay dedejinta habka dayactirka mindhicirka iyo kicinta horumarka xiidmaha. Waxaa jira hab gaar ah oo butyric acid uu u shaqeeyo iyada oo loo marayo farsamo looga hortago caabuqa, oo ah isku-darka Host Defense Peptides (HDPs), oo sidoo kale loo yaqaan peptides ka hortagga microbial, kuwaas oo ah qaybo muhiim ah oo ka mid ah difaaca jirka. Waxay leeyihiin firfircooni ballaaran oo ka hortagga microbial ah oo ka dhan ah bakteeriyada, fangaska, dulinleyda iyo fayrasyada ku dheggan kuwaas oo aad ugu adag in cudur-sidaha uu yeesho iska caabin ka dhan ah. Defensins (AvBD9 & AvBD14) iyo Cathelicidins waa labada qoys ee ugu waaweyn ee HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) oo laga helo digaagga oo ay kobciso kaabista aashitada butyric. Daraasad ay samaysay Sunkara et al. Maamulka dibadda ee aashitada butyric waxay kicisaa koror la taaban karo oo ku yimaada muujinta hidda-wadaha HDP sidaas darteedna waxay kor u qaaddaa awoodda iska caabbinta cudurrada ee digaagga. Waxaa xiiso leh, dhexdhexaad ah iyo LCFAs yar.

Faa'iidooyinka caafimaad ee Tributyrin
Tributyrin waa hordhac u ah asiidhka butyric kaas oo u oggolaanaya molecules badan oo ah asiidhka butyric in si toos ah loogu geeyo xiidmaha yar sababtoo ah farsamada esterification. Sidaas darteed, fiirsashada ayaa laba ilaa saddex jeer ka badan marka loo eego alaabada dahaarka leh ee caadiga ah. Esterification waxay u oggolaanaysaa saddex molecules asiidhka butyric in lagu xidho glycerol kaas oo kaliya uu jebin karo lipase-ka ganaca ee endogenous.
Li et. al. waxay sameeyeen daraasad difaaceed si ay u helaan saameynta faa'iidada leh ee tributyrin ee cytokines-ka pro-bararka ee broilers-ka ee lagu loolamayo LPS (lipopolysaccharide). Isticmaalka LPS si weyn ayaa loo aqoonsaday inuu kiciyo bararka daraasadaha sidan oo kale ah maadaama uu kiciyo calaamadaha bararka sida IL (Interleukins). Maalmihii 22, 24, iyo 26 ee tijaabada, broilers-ka waxaa lagu qasbay maamul gudaha caloosha ah oo ah 500 μg/kg BW LPS ama saline. Kaabista cuntada ee tributyrin oo ah 500 mg/kg ayaa joojisay kororka IL-1β & IL-6 taasoo soo jeedinaysa in kaabista ay awood u leedahay inay yareyso sii deynta cytokines-ka pro-bararka sidaas darteedna ay yareyso caabuqa mindhicirka.

Soo Koobid
Iyadoo la xaddiday isticmaalka ama gebi ahaanba la mamnuucay dhiirrigeliyeyaasha koritaanka antibiyootiga qaarkood sida waxyaabaha lagu daro quudinta, waa in la sahamiyaa xeelado cusub oo lagu hagaajinayo laguna ilaalinayo caafimaadka xoolaha beeraha. Hufnaanta xiidmaha waxay u adeegtaa isku-xir muhiim ah oo u dhexeeya agabka ceeriin ee quudinta qaaliga ah iyo kor u qaadista koritaanka ee digaagga digaagga. Gaar ahaan aashitada Butyric waxaa loo aqoonsan yahay inay tahay kor u qaade xooggan oo caafimaadka caloosha iyo mindhicirka ah oo horey loogu isticmaalay quudinta xoolaha in ka badan 20 sano. Tributyrin waxay keentaa aashitada butyric xiidmaha yar waxayna aad waxtar ugu leedahay saameynta caafimaadka mindhicirka iyadoo la dedejinayo habka dayactirka mindhicirka, dhiirigelinta horumarka ugu wanaagsan ee villi iyo wax ka beddelka falcelinta difaaca jirka ee marinnada mindhicirka.

Hadda iyadoo antibiyootiga la joojinayo, aashitada butyric waa qalab weyn oo lagu taageerayo warshadaha si loo yareeyo saameynta xun ee dysbacteriosis kaas oo soo ifbaxaya isbeddelkan awgiis.