Aashitada Guanylacetic, oo sidoo kale loo yaqaan guanylacetic acid, waa amino acid analogue oo laga sameeyay glycine iyo L-lysine.

Guanylacetic acid waxay soo saari kartaa creatine iyadoo la adeegsanayo katalisyada enzymes-ka waana shardiga kaliya ee loogu talagalay isku-darka creatine. Creatine waxaa loo aqoonsan yahay inay tahay kayd tamar, shaqadeeda ugu weynna waa inay samayso creatine fosforylated iyadoo la adeegsanayo creatine kinase.

Ka qayb qaado safarka adenosineWareegga hosphate (ATP). Marka tamarta ATP aysan ku filnayn, fosfocreatine si dhakhso ah ayuu kooxda fosfate ugu wareejiyaa adenosine diphosphate iyada oo loo marayo creatine kinase waxayna dib ugu celisaa adenosine triphosphate.

 

Isticmaalka xoolaha:

Ku darista 0.12%, 0.08%, iyo 0.04% guanylacetic acid cuntada 120 neef oo la quudiyo oo ah ido Tan ah oo miisaankoodu yahay qiyaastii 20 kiilo garaam, siday u kala horreeyaan, waxay muujisay in ku darista 0.12% iyo 0.08% guanylacetic acid ay si weyn u kordhisay miisaanka maalinlaha ah, dufanka gudaha, iyo borotiinka, iyo sidoo kale hoos u dhac weyn oo ku yimid dufanka hilibka.

 

Ku darista 0.08%asiidh guanylacetic ahBoqolkiiba hilibka saafiga ah ayaa kordhay 9.77%. Iyadoo la adeegsanayo habka wax soo saarka gaaska in vitro, waxaa la darsay saameynta ku darista heerarka kala duwan ee guanylacetic acid ee rumen ee lo'da jaalaha ah. Waxaa la ogaaday in ku darista 0.4% guanylacetic acid ay si weyn u kordhisay wax soo saarka gaaska, iyo isku-darka nitrogen ammonia marka hore way korodhay ka dibna way yaraatay.

Sidaa darteed, waxaa la qiyaasi karaa in ku darista aashitada guanylacetic ee quudinta maalinlaha ah ay hagaajin karto deegaanka gudaha ee rumen iyo habka halsano ee lo'da jaalaha ah.

Codsiga digaagga:

Ku darista 800 mg/kg, 1600 mg/kg, 4000 mg/kg, iyo 8000 mg/kg oo ah asiidhka guanylacetic ee quudinta maalinlaha ah ee broilers waxay muujisay in ku darista 800-4000 mg/kg oo ah asiidhka guanylacetic ee quudinta ay si weyn u kordhisay korodhka miisaanka maalinlaha ah ee broilers, taasoo hoos u dhigtay saamiga quudinta iyo miisaanka ee broilers-ka 22-42 maalmood da'da. Ku darista 8000 mg/kg oo ah asiidhka guanylacetic ayaa hagaajisay tilmaamayaasha biochemical-ka ee serum-ka sida nitrogen urea, tilmaamayaasha joogtada ah ee dhiigga, iyo wadarta bilirubin Ma jirin saameyn weyn oo ku timid tilmaamayaasha xubnaha waaweyn, taasoo muujinaysa in ku darista 8000 mg/kg oo ah asiidhka guanylacetic ee quudinta maalinlaha ah ee broilers-ka ay tahay mid la dulqaadan karo.

Ku darista 200 mg/kg, 400 mg/kg, 600 mg/kg, iyo 800 mg/kg oo ah guanylacetic acid quudinta broiler waxay muujisay koror weyn oo ku yimid celceliska miisaanka maalinlaha ah marka la barbar dhigo kooxda xakamaynta. Natiijooyinka ugu wanaagsan waxaa la gaaray markii heerarka lagu daray ay ahaayeen 600 iyo 800 mg/kg.

Si loo barto saameynta aashitada guanylacetic ee tayada shahwada ee diiqa, diiqa 20 jirka ah ee 28 toddobaad jir ah ayaa la doortay si ay u quudiyaan cunto ka kooban 0%, 0.06%, 0.12%, iyo 0.18% aashitada guanylacetic. Natiijooyinka cilmi-baaristu waxay ogaadeen in ku darista 0.12% guanylacetic acid cuntada ay si weyn u kordhisay tirada shahwada, fiirsashada shahwada, iyo dhaqdhaqaaqa shahwada ee diiqa, taasoo muujinaysa in ku darista aashitada guanylacetic cuntada ay si wax ku ool ah u horumarin karto tayada shahwada. Ku dar 0.0314%, 0.0628%, 0.0942%, iyo 0.1256% guanylacetic acid quudinta maalinlaha ah ee digaagga, oo deji laba kooxood oo xakameynaya (kooxda xakamaynta 1 waa quudin ku salaysan dhir iyada oo aan wax walax ah lagu darin, kooxda xakamaynta 2na waa quudin lagu daray cunto kalluun). Lixda kooxood ee kor ku xusan ee quudinta maalinlaha ah waxay leeyihiin heer isku mid ah oo tamar iyo macdan ah.

Natiijooyinka tijaabada ah waxay muujinayaan in heerarka miisaanka oo kordha ee afarta kooxood ee leh aashitada guanylacetic iyo kooxda xakamaynta 2 ay ka sarreeyaan kuwa kooxda xakamaynta 1, Kooxda xakamaynta 2 waxay lahayd saameynta miisaanka oo kordha ugu fiican, waxaana ku xiga kooxda aashitada guanylacetic 0.0942%; Kooxda xakamaynta 2 waxay lahayd saamiga ugu fiican ee walxaha iyo miisaanka, waxaana ku xiga kooxda aashitada guanylacetic 0.1256%.

Codsiga digaagga:

Ku darista 800 mg/kg, 1600 mg/kg, 4000 mg/kg, iyo 8000 mg/kg oo ahasiidh guanylacetic ahQuudinta maalinlaha ah ee digaagga digaagga ayaa muujisay in ku darista 800-4000 mg/kg oo guanylacetic acid ah quudinta ay si weyn u kordhisay korodhka miisaanka maalinlaha ah ee digaagga ...

Si loo barto saameynta aashitada guanylacetic ee tayada shahwada ee diiqa, diiqa 20 jirka ah ee 28 toddobaad jir ah ayaa la doortay si ay u quudiyaan cunto ka kooban 0%, 0.06%, 0.12%, iyo 0.18% aashitada guanylacetic. Natiijooyinka cilmi-baaristu waxay ogaadeen in ku darista 0.12% guanylacetic acid cuntada ay si weyn u kordhisay tirada shahwada, fiirsashada shahwada, iyo dhaqdhaqaaqa shahwada ee diiqa, taasoo muujinaysa in ku darista aashitada guanylacetic cuntada ay si wax ku ool ah u horumarin karto tayada shahwada. Ku dar 0.0314%, 0.0628%, 0.0942%, iyo 0.1256% guanylacetic acid quudinta maalinlaha ah ee digaagga, oo deji laba kooxood oo xakameynaya (kooxda xakamaynta 1 waa quudin ku salaysan dhir iyada oo aan wax walax ah lagu darin, kooxda xakamaynta 2na waa quudin lagu daray cunto kalluun). Lixda kooxood ee kor ku xusan ee quudinta maalinlaha ah waxay leeyihiin heer isku mid ah oo tamar iyo macdan ah. Natiijooyinka tijaabada ah waxay muujinayaan in heerarka miisaanka oo kordha ee afarta kooxood ee leh aashitada guanylacetic iyo kooxda xakamaynta 2 ay ka sarreeyaan kuwa kooxda xakamaynta 1, Kooxda xakamaynta 2 waxay lahayd saameynta miisaanka oo kordha ugu fiican, oo ay ku xigto 0.0942%asiidh guanylacetic ahKooxda xakamaynta 2aad waxay lahayd saamiga ugu fiican ee walxaha iyo miisaanka, waxaana ku xigay kooxda guanylacetic acid 0.1256%.