Tributyrin (TB)iyoMonolaurin (GML), oo ah waxyaabaha lagu daro quudinta shaqada, waxay leeyihiin saameyn nafsaani ah oo badan oo ku saabsan beerista digaagga lakabka ah, taasoo si weyn u hagaajinaysa waxqabadka wax soo saarka ukunta, tayada ukunta, caafimaadka xiidmaha, iyo dheef-shiid kiimikaadka dufanka. Hoos waxaa ku qoran shaqooyinkooda iyo farsamooyinkooda ugu muhiimsan:

1. Hagaaji waxqabadka wax soo saarka ukunta
Glycerol Monolauret(GML)

Ku darista 0.15-0.45g/kg GML cuntada digaagga dhalaya waxay si weyn u kordhin kartaa heerka wax soo saarka ukunta, waxay yareyn kartaa heerka beddelka quudinta, waxayna kordhin kartaa miisaanka ukunta ee celceliska ah.
Daraasad ayaa muujisay in 300-450mg/kg GML ay hagaajin karto heerka wax soo saarka ukunta ee digaagga dhalaya iyo inay yarayn karto heerka ukunta cilladaysan.

Tributyrin (TB) 

Tijaabada digaagga digaagga digaagga, 500mg/kg TB waxay dib u dhigi kartaa hoos u dhaca heerka wax soo saarka ukunta marxaladda dambe ee dhalmada ukunta, waxay hagaajin kartaa xoogga qolofta ukunta, waxayna yareyn kartaa heerka dillaaca ukunta.
Marka lagu daroGML(sida qaacidada shatiga leh) waxay sii dheereyn kartaa muddada ugu sarreysa ee wax soo saarka ukunta waxayna wanaajin kartaa faa'iidooyinka dhaqaale.

2. Hagaaji tayada ukunta

Shaqada GML
Kordhi dhererka borotiinka, unugyada Haff (HU), oo kor u qaad midabka jaallaha.
Hagaaji isku-dhafka aashitada dufanka leh ee jaallaha ukunta, kordhi aashitada dufanka leh ee polyunsaturated (PUFA) iyo aashitada dufanka leh ee monounsaturated (MUFA), oo yaree tirada aashitada dufanka leh ee buuxa (SFA).

Marka la qaato qiyaas dhan 300mg/kg, GML waxay si weyn u kordhisay adkeysiga qolofta ukunta iyo borotiinka cad ee ukunta.

ShaqadaTB

Kordhi xoogga qolofta ukunta oo yaree heerka jabitaanka qolofta (sida yareynta 58.62-75.86% tijaabooyinka).

Kor u qaadida muujinta hiddo-sidayaasha la xiriira dhigista kalsiyum-ka ilmo-galeenka (sida CAPB-D28K, OC17) oo hagaaji kalsiyum-ka qolofta ukunta.

3. Nidaaminta dheef-shiid kiimikaadka lipid iyo shaqada antioxidant-ka
Shaqada GML
Yaree triglycerides-ka serum-ka (TG), kolestaroolka guud (TC), iyo kolestaroolka lipoprotein-ka ee cufnaanta hooseeya (LDL-C), oo yaree dhigista dufanka caloosha.
Hagaaji firfircoonida serum superoxide dismutase (SOD) iyo glutathione peroxidase (GSH Px), yaree maadada malondialdehyde (MDA), iyo kor u qaadida awoodda antioxidant-ka.
ShaqadaTB
Yaree heerka triglyceride-ka beerka (10.2-34.23%) oo kor u qaad hiddo-sidayaasha la xiriira oksaydhka dufanka (sida CPT1).
Yaree heerarka phosphatase-ka alkaline ee serum (AKP) iyo MDA, oo kordhi awoodda antioxidant-ka guud (T-AOC).

4. Hagaajinta caafimaadka xiidmaha
Shaqada GML
Kordhi dhererka villus iyo saamiga villus ilaa villus (V/C) ee jejunum si loo hagaajiyo qaab-dhismeedka xiidmaha.
Hoos u dhig arrimaha keena bararka (sida IL-1 β, TNF - α), kor u qaad arrimaha ka hortagga bararka (sida IL-4, IL-10), oo kor u qaad shaqada xannibaadda xiidmaha.
Hagaaji qaab-dhismeedka microbiota cecal, yaree saamiga Proteobacteria, iyo kor u qaadida koritaanka bakteeriyada faa'iidada leh sida Spirogyraceae.
Shaqada Qaaxada
Hagaaji qiimaha pH ee xiidmaha, kor u qaad faafitaanka bakteeriyada faa'iidada leh (sida lactobacilli), iyo joojinta bakteeriyada waxyeelada leh.
Kordhinta muujinta hidda-wadaha borotiinka isku-xidhka adag (sida Occludin, CLDN4) waxay kor u qaadaysaa hufnaanta xannibaadda xiidmaha.

5. Saamaynta nidaaminta difaaca jirka
Shaqada GML
Hagaajinta tusmada beeryarada iyo tusmada thymus, kor u qaad shaqada difaaca jirka.
Yaree calaamadaha bararka serum-ka sida aspartate aminotransferase (AST) iyo alanine aminotransferase (ALT).
Shaqada Qaaxada
Yaree jawaabta bararka xiidmaha adigoo nidaaminaya habka soo-dhoweeyaha Toll-like (TLR2/4).

6. Saamaynta codsiga wadajirka ah
Cilmi-baaris shati-qaadis ah ayaa muujisay in isku-darka GML iyo TB (sida 20-40 TB+15-30 GML) ay si wada jir ah u hagaajin karaan heerka wax-soo-saarka ukunta ee digaagga dhalaya (92.56% vs. 89.5%), ay yareyn karaan caabuqa tuubada, ayna dheereyn karaan muddada ugu sarreysa ee wax-soo-saarka ukunta.

Soo Koobid:

Glycerol monolaurate (GML)iyoTributyrin (TB)waxay leeyihiin saameyn dhammaystiran oo ku saabsan beerista digaagga:

GMLdiiradda saarayaahagaajinta tayada ukunta, nidaaminta dheef-shiid kiimikaadka dufanka leh, iyo dhaqdhaqaaqa antioxidant-ka;
TBdiiradda saarayaahagaajinta caafimaadka xiidmaha iyo dheef-shiid kiimikaadka kalsiyum;
Isku-darka ayaa awood u lehSamee saameyn isku-dhafan, si buuxda u hagaaji waxqabadka wax soo saarka iyo tayada ukunta.